In order to guide the missile in the direction of the target in real time and strike accurately, a method based on longitude and latitude is proposed to solve the azimuth and distance between the missile and the target point. In this paper, the longitude and latitude of the projectile and the target are taken as known parameters, and the space model of the coordinate points of the projectile and the target is established according to the spatial position relationship. According to the spherical and spatial geometric relationship, the solution of the distance and azimuth angle is obtained, and the comparison is verified by using Google Earth software. The calculation results show that the guidance method is simple and effective, and has application value.