To demonstrate the ability of laser guided air-to-ground missile to attack moving target, the flight test technology for laser guided air-to-ground missile weapon system attacking mobbing target was proposed. The evaluation index system for operation was established according to the operating principle of UAV laser guided missile weapon system, integrated test and evaluation method was used to analyze operator’s qualitative evaluation and quantitative results which came from semi-physical simulation and ground test. The technical requirements of the targets were described in detail. The test methods and contents of airborne and external data testing were given, and the suggestion of operation was given to users. At last, the validity and rationality of the method are proved by the real flight test result. The designing idea and flight test method can provide reference for the flight test and evaluation of laser-guided missile weapon system.