In view of the disadvantages of the typical weighting methods, a new method of weight combination based on preference coefficient is proposed. The index system of missile cooperative combat effectiveness is constructed, and the two weighting methods of analytical hierarchy process (AHP) and entropy weight method and the combination of the two methods are used to calculate the weight of the effectiveness evaluation model and fuzzy evaluation, and the results are analyzed. The simulation results show that the method verifies the rationality of the application of combination weighting method in effectiveness evaluation.