In order to improve the structural strength reliability of the bullet when the bullet is launched, the simulation method of launching strength reliability of the bullet based on ISIGHT software is analyzed. The Parametric finite element simulation model of bullet launching intensity based on ABAQUS software was established by using Python language, and the random quantity of each influencing factor was generated by using Monte Carlo description sampling method based on variance reduction technology, and ABAQUS software was integrated by ISIGHT software. The parameterized driving cycle simulation of the warhead launching intensity under multiple random working conditions is completed. The reliability evaluation of the launching strength of the bullet is completed. The example results show that the method is effective, and it provides a feasible method for the reliability analysis of the bullet structure.