Aiming at the problem that the function requirement level of autoloader is fuzzy, a performance index system is proposed based on the quality characteristics of system engineering equipment, and a hierarchical model is established by using interpretative structural modeling (ISM) method to evaluate the importance of the index. Through the qualitative analysis of the indicators by the interpretative structural model, the hierarchical model diagram and the hierarchical order of the fuzzy importance are obtained. Through the quantitative analysis and comparison of the 3 most critical indicators by the AHP, the order of their importance is obtained. 2 results are obtained by combining the ISM method and the analytic hierarchy process. The order of the importance of the autoloader’s key performance indexes and the hierarchical structure of the overall indexes are obtained. The results show that the evaluation method provides a new idea for the development and improvement of the autoloader.