In order to solve the difficult of sensitivity analysis of the terminal sensitive projectile system, using the highly non-linear reflecting capability of neural network and the scientific computing ability of matlab, some factor which affect capability about terminal sensitive projectile is being sensitivitic analyzed. From it an optimal arrangement of several main factors affecting the system efficiency was obtained. After analysis of the results of the optimization, showing that the optimal arrange-ment of those influencing factors are wholly in accordance with the actual state, and that the method can provide scientific foundations for the future efficiency research of terminal-sensitive projectile systems.