In order to prove whether the strength of multiple rocket launchers' frame is meet the requirement of the march or not, based on ADAMS and Abaqus software, establish rigid-flexible coupled model of multiple rocket launcher. Through ADAMS flexible theory to establish rigid-flexible coupled model of rocket launcher running process, use dynamic simulation to acquire displacement of exterior point in vertical direction. Take this as boundary condition, calculate frame stress and strain in Abaqus, then verify it by simulation test. The test results show that: combine two software methods can avoid shortcomings of taking a long time and hard to converge to calculate complex models as well as the inaccuracy of model in multi-body dynamics software.