For improving internal energy Gatling gun dynamic response performance, taking certain type high RF small caliber ship borne artillery as example, carry out optimal design for dynamic response, establish Gatling gun virtual prototype model, carry out flexible processing for barrel and dynamic simulation for overall gun, and acquire Gatling gun dynamic response feature curve by calculation. Based on Isight software platform, carry out multi-target optimization of simulation model, carry out firing dispersion simulation based on optimal artillery dynamic response results. The research results show that the longitudinal vibration displacement of the muzzle was reduced by 1.43%, the maximum recoil resistance was reduced by 7.23%, and the maximum displacement of the recoil was reduced by 5.63%, the shooting intensity had been improved. This research can provide a reference for improving the firing accuracy of the self-energy Gatling gun and the structure optimization of the self-energy Gatling gun.