The traditional parallel bus embedded system information exchange and high speed data acquisition can not satisfy the requirements of high transmission bandwidth and big data IO collection. Design high speed signal board based on VPX architecture. The high signal board design is based on VPX architecture. Uses 10G BASE-KR standard to carry out high speed PCB board design, and verifies it by simulation and design. The simulation results show that the design can meet the requirements of impedance consistency and high speed.