In view of the recoil force and recoil displacement were too large during tests of the gatling gun weapon, research on certain type gatling gun, and the method of the optimization design of buffer spring device based on isight is proposed. The gatling gun weapon virtual prototype model was built based on the dynamics analysis software ADAMS, and the results were analyzed. Then, the maximum recoil force is set as the target function based on the isight multidisciplinary optimization techniques, and carry on sensitivity analysis to the design parameters of the buffer spring by using the optimal design method of Latin hypercube under no more than 19 mm in recoil displacement constraints. The ADAMS running program is integrated with isight, the design parameters of buffer spring is carried out parallel optimization by using multi-target genetic algorithm NSCG-II. The results indicate that compared with the original scheme, recoil force of optimized design parameters decrease significantly, and the design method can provide a reliable reference basis for the optimization design of buffer spring device.