The ship-based missile launch system which mounted under the board, is easy to be ignored of wind load. According to that, the wind load influence on the missile is simulated and analyzed. Analyze the missile wind load feature under high sea condition, establish wind load models. According to missile ejection situation, regarded the wind load as the variable torque and the constant force, use 3D modeling software to establish launching model and introduce it into ADAMS software to carry out model parameter and constraint conditions setting. Focusing on the missile ejection situation, height deviation and attitude angle, the ejection of missile in the condition of wind load and no wind load is simulated. The simulation results show that the displacement in horizontal direction which caused by wind load is obvious enough, while the influence on attitude angle and ejection height is little. The study has decent guidance in practice.