In order to solve the problem of the high production cost of unmanned supermarkets and unmanned delivery vehicles, a fully automatic unmanned vending and selling system was designed. By using the key technologies such as face recognition based on FaceID, membership record, big data sales, wireless anti-theft technology and so on, the control of incoming and outgoing customers traffic was achieved. Meanwhile, the unmanned delivery vehicle can avoid obstacles and accomplish the delivery task accurately by taking the advantage of mobile sales platform, RTK high-precision positioning, and the control algorithm of inertial navigation system. We design and develop this sales management system of unmanned supermarket by using Spring Boot, and achieve the integration of automatic sales and delivery of goods. The experimental results show that this fully automatic unmanned vending and selling system can effectively increase the income of the unmanned supermarkets by 60% to 80% so that it has great promotional value.