In order to solve the problem of inaccuracy resulting from experience type decision, research on integration and optimization decision of manufacturing, inventory and distribution routing. According to basic principle of optimization, analyze the wrong network structure of coordination decision, establish the MIL optimization model of equipment maintenance material supply support based on PRP optimization decision theory, and use small scale example to verify model effectiveness. The verification results show that the research can provide reference for the implementation of low-cost and high-precision equipment maintenance material supply support work.