In order to promote the transformation and upgrading of science and technology industrial manufacturing, the integration of the new generation information technology and intelligent manufacturing advanced production mode is discussed. The successful practice of the integration of the new generation information technology and advanced manufacturing in foreign countries is analyzed. Based on the information foundation of the intelligent manufacturing industry in China, the suggestion of the application and implementation of the new generation information technology in the production mode of the intelligent manufacturing industry in China is put forward. The results show that the analysis can provide reference for the industrialization and informatization construction of manufacturing industry in China.