Aiming at the problem that the air pressure at high altitude affects the energy efficiency of weapon shooting, a systematic method for compiling the firing table of cartridge at high altitude is proposed. Through the analysis and processing of the plateau and plain test data, the change of the exterior ballistic characteristic quantity of the cartridge under the plateau and plain conditions is compared, the reasons are analyzed and the laws are summarized theoretically, and a set of systematic method for compiling the plateau firing table of the cartridge is obtained. The calculation verification results show that this method can improve the accuracy of firing table significantly.