In order to realize the continuous kneading and safe filling of kneading equipment, a horizontal multi-chamber continuous kneading equipment was designed. The temperature of each chamber, the rotating speed of the functional blades and the feeding speed directly affect the filling quality, the filling density and the equipment capacity of the product. The results show that with the difference of the material formula, the effective combination of the functional blades, the optimization of the blade shape and the selection of the material screen in each chamber can effectively improve the kneading uniformity and the kneading quality of the product.