According to the actual demand of charge quality supervision of missile warhead, the characteristics of typical charge technologies (casting charge, pressing charge, PBX casting charge) of warhead at present are analyzed. Through comparative analysis, combined with the development needs of missile warhead, the key points of charge quality supervision are put forward, and more detailed control measures are drawn up for charge quality supervision of warhead. The results show that the quality supervision points and control measures can effectively guide the relevant personnel to control the warhead charge quality and improve the supervision efficiency.