According to the dual requirements of the penetration depth and aperture of the front charge of the fortification warhead, the orthogonal optimization scheme was designed based on the 80 mm caliber charge platform, and the two-dimensional numerical simulation was carried out by using the finite element software AUTODYN to analyze the influence of the structural parameters of the front charge liner and clapboard of the fortification warhead on the jet formation and penetration into the concrete target. The penetration depth L and the dimensionless number γ are proposed as the evaluation indexes, and the order of the influence of the structural parameters on the two indexes is found out, and the best combination of the wall thickness of the liner, the top height of the liner, the thickness of the clapboard and the diameter of the clapboard is obtained. On this basis, the static test of the reinforced concrete target is carried out. The results show that the numerical simulation is in good agreement with the experiment, and the optimized penetration aperture is increased by 20% compared with the original structure. This method can provide a reference for the further study of the charge technology of the fortification warhead.