Aiming at the increasingly complex combat environment, the autonomous replanning technology of air-to-surface simultaneous multi-target attack is studied. By analyzing the necessity of autonomous replanning of air attack, this paper expounds the foreign research status represented by F-35, and focuses on the design of replanning system of air and surface simultaneous multi-target attack. It includes functional composition, working logic and the difficult problems in the design, such as the re-planning of the projection pipeline, the re-planning of the attack route, the re-planning of the attack sequence and the pre-estimation of the lethality. The results show that the study can lay a solid foundation for further engineering implementation.