Aiming at the problem that it is difficult to select the spare parts preset point in the field of cross-regional mobile combat equipment maintenance support, a method of using genetic algorithm to solve the model of spare parts preset point location is proposed. Under the condition of optimal spare parts support time and benefit, a fixed-point radiation support spare parts preset point location model is constructed. The genetic algorithm is used to give the solution method of the spare parts preset point location model. The model and its solution method are simulated and verified, and the optimal equipment maintenance spare parts preset point is obtained. The simulation results show that for 15 fixed-point radiation maintenance support spare parts preset points, when 4 of the spare parts preset points are selected, the workload of each point is about 0.63, and the value is reasonable, which proves that the algorithm can effectively solve the problem of support delay.