To enhance the braking efficiency of commercial vehicles, reduce the response time of the braking system, optimize the air drying effect, and facilitate the layout of chassis space, the air handling system has been optimized. Through an in-depth analysis of the technical scheme, performance indices, working principles, and vehicle matching principles of commercial vehicle air handling systems, this study focuses on the impact of core indicators such as intelligent air handling unit efficiency, air storage volume, and air regeneration efficiency on braking performance. Intelligent pressure control technology was employed to refine the design, which was subsequently validated through road tests. The results indicate that air regeneration efficiency has been improved, achieving precise control and efficient utilization of air. A reasonable configuration of air storage volume ensures stable braking efficiency; the response time has been shortened, the braking distance reduced, and the overall braking performance of the vehicle significantly enhanced.