Aiming at the characteristics of complex indexes and fuzzy results in man-machine-environment (MME) engineering evaluation of wheeled equipment, an evaluation method for MME engineering of wheeled equipment was proposed based on combinatorial weighted cloud model. According to the mission tasks and structural characteristics of wheeled equipment, the evaluation index system of MME engineering of wheeled equipment was established. Analytic hierarchy process (AHP) and entropy weight (EW) were used to assign weights, and a comprehensive cloud model of MME engineering evaluation of wheeled equipment was established. The results show that this method can truly reflect the randomness of the evaluation process and the fuzziness of the evaluation results. It is more scientific than the traditional evaluation method, and provides a new method for the evaluation test of MME engineering of wheeled equipment.