In order to improve killing capability of anti-aircraft missile effectively, the modeling and simulation of the shortrange anti-aircraft missile intercepting cruise missile is constructed. According to the analysis on detecting zone and killing zone, compute the launching zone of short-range anti-aircraft missile. The model of anti-aircraft missile interception for the cruise missile is constructed under guide rules. On the basis of the killing zone of short-range anti-aircraft missile and the detecting distance of search and track radar, the launching zone of short-range anti-aircraft missile is worked out. Then the simulation is conducted in MATLAB. Calculate the times of interception and the distance of every interception. In different killing zone, calculate the connection of missile speed and interception times. This model has universality in some extent, so it can provide reference to improve the technical performance and tactical performance of the missile.