According to the characteristics of ground-to-air missile and anti-aircraft gun integration weapon against cruise missiles, use the queue theory to establish the ground-to-air missile and anti-aircraft gun integration weapon firing efficiency evaluation model. The model shows the way of calculating the efficiency of ground-to-air missile and anti-aircraft gun integration weapon against cruise missiles, and considers the influence to interception efficiency caused by the number of the shooting in the area intercepting, and an example to demonstrate the feasibility and effectiveness of the model. The model has some theoretical and practical value to the program of fire using and improving operational effectiveness.