Aiming at the problem during bullet machine press of a group of several rounds of ammunition, build a simple three-D model for the bullet press machine’s structure. During design of the bullet press machine of a certain kind of ammunition’s automatic assembly and production line, set up a virtual machine through SolidWorks and use SolidWorks Simulation, the mechanical and simulation design software, to make statistic framework simulation analysis for the machine model, therefore to get the maximum stress and distortion displacement of the major critical components. After that, make optimized design for the critical parts. Result shows that the method works practically and could make a theoretical reference for design of bullet press machine and similar equipments.