According to features of Air-defense warfare to surface formation, construct firepower distribution optimization solution based on Multi-Agent system. Air-defense warfare is one of the most important forms in modern naval battles, study on firepower distribution strategy using based on Multi-Agent system to solve firepower dynamic allocation problem. This paper presents a method that abstract surface warship to be an adaptive agent and reach optimization purposes in the end. Compare to the traditional genetic algorithm with static mathematic model, the MAS consider more about all ships’ cooperation, coordinating. Simulation result shows that the method can provide an effective scheme for solve firepower distribution problem, and provide reference for air-defense warfare target assignment.