For obtaining correct and reliable information from the intelligence, the application of the technique of multi-sensor information fusion in space reconnaissance is studied. Firstly, introduce the basic definition of multi-sensor information fusion and multi-sensor information fusion based on D-S theory. Secondly, put emphasis on analyzing the application of the D-S theory in multi-sensor space reconnaissance information fusion. Finally, an example is applied to verify the method. The result indicates the method can make up for a deficiency of half-baked and uncertain single information, improve the reliability and accurateness of the fusion information in space reconnaissance.