The strike capability of time sensitive target is the capability to quickly strike the fleeting target on battle fields. This article first describes the concept of time sensitive target and then depicts the time sensitive strike chain. Decision variables and constraint conditions are adopted for clarifying the optimization of time sensitive target strike chain. The command-and-control mode of time sensitive target strike chain with network-centric governing, decision maker governing, sensor governing and gunner governing is pointed out for optimization of time sensitive target strike chain. Three points on optimization of time sensitive target strike are summarized at the end. The research on the problem of time sensitive targets strike-chain optimization can enable combat forces real-time, coordination and synchronization, integration and significantly improve combat effectiveness.