In order to improve the design level of anti-tank missile weapon in informationization warfare, a method of informative design of indirect aiming anti-tank missile weapon system is proposed. Based on the purpose and criterion of informative design, informative design flow of anti-tank missile weapon is presented. The design content of information system of anti-tank missile weapon is described in detail form 8 aspects. Simulation results show the advantage of this design method such as short design assessment cycle, clear and reasonable design flow, rapid reaction and strong resilience.