On basis of particular superiority of naval gun guided projectile (laser-guided) in island-reef war, we do research on its operation application. The thesis analyze the characteristic of naval gun guided projectile in island-reef war firstly, then conclude the firing process at island-reef target, firing command with different platform-borne laser indicator support are done at last. The result shows that compared with missile and ordinary naval gun ammunition, naval gun guided projectile are fit for the island-reef environment better. The research has important application value on operational command and firing support of naval gun guided projectile in island-reef.