Aiming at the simulation problem that antagonism between ship-to-air missile and snake maneuvering anti-ship missile, simulate the antagonism. The importance of simulation of antagonism between ship-to-air missile and snake maneuvering anti-ship missile is analyzed, three-dimensional movement is decomposed two-dimensional in the plumb and level plane, then composing the movement contrail, three-dimensional proportional guidance trajectory is achieved. It analyzes the order of crab angle when anti-ship missile carries on snake maneuver and describes the simulation flow chart. The simulation result indicates that the model possesses applicability.