Based on ship-to-air missile operation characteristics in operational mission and fight, use simulation experiment design method to research the influence of ship-to-air missile system and subsystem reliability and maintainability on missile weapon system fighting efficiency. Establish reliability model, maintenance model and using model of ship-to-air missile system. Set different combating applications background and put forward influence indexes of reliability maintenance on combating performance. Carry our test design and simulation research to combating performance influence under set 3 typical combating modes. The simulation results show that the method can take to test comprehensive in scope, stable effect and low cost, can be repeated adjustment to find the greatest impact of various factors of growth and change interval on system performance.