In practical applications, it often needs to establish the ordinary differential equations which physical quantities change over one quantity, such as time, temperature, etc. Excel is widely used in the fields of economy, finance, engineering, research, teaching and so on. It has some practical significance to solve the ordinary differential equations with Excel. This article describes two kinds of Excel method to solve ordinary differential equations, using VBA programming and calling Matlab. All programs run through the debugger and run well in the practical programming environment.