For the problem of solving global optimal solution of anti-ship missiles route planning under multi-directional saturation attacks, this paper carries out a reasonable setting of anti-ship missiles route planning under multi-directional saturation attacks. Based on the basic constraint condition of anti-ship missile route planning, establish the route planning model, which can minimum the self-control flight distance, based on this, turn the problem about anti-ship missiles route planning under multi-directional saturation attacks to the problem about solving the key waypoints of anti-ship missiles around it with plane geometry knowledge. The solving method is formulated that can ensure the routes of anti-ship missiles quickly and the simulation is made for validating it. Simulation calculation shows that the method can construct simple routes quickly for anti-ship missiles under multi-directional saturation attacks, which can be up to the requirements for multi-directional attack and beneficial to project implementation.